BDBM50054601 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide::5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide::5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide::Arava (TN)::CHEMBL960::LEFLUNOMIDE::alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide

SMILES Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N

Data  14 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50054601   

TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.77E+5nMAssay Description:Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Rattus norvegicus)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.12E+5nMAssay Description:Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50054601(5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazole...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed