BDBM50058225 CHEMBL45244::N-((4-(2-cyanophenyl)piperazin-1-yl)methyl)-3-methylbenzamide::N-[4-(2-Cyano-phenyl)-piperazin-1-ylmethyl]-3-methyl-benzamide::PD-168077

SMILES Cc1cccc(c1)C(=O)NCN1CCN(CC1)c1ccccc1C#N

InChI Key InChIKey=DNULYRGWTFLJQL-UHFFFAOYSA-N

Data  21 KI  1 IC50  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50058225   

TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H] Spiperone from human D4.4 receptor expressed in CHO cells by competitive radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  8.70nMAssay Description:Binding affinity for human Dopamine receptor D4 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  8.71nMAssay Description:Binding affinity of compound towards human dopamine receptor D4 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  9nMAssay Description:Binding affinity towards cloned human Dopamine receptor D4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-spiperone from human D4 receptor assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  17.0nMAssay Description:Binding affinity towards human dopamine receptor D4 expressed in CHO cells was determined by using [3H]thymidine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Universit£

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  25nMAssay Description:Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (high-affinity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor [16-465](Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  168nMAssay Description:Binding affinity of the compound at alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  177nMAssay Description:Binding affinity of the compound at Alpha-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Mus musculus (Mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  385nMAssay Description:Binding affinity of the compound at 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H] Spiperone from human D2S receptor expressed in CHO cells by competitive radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H] Spiperone from human D2L receptor expressed in CHO cells by competitive radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  2.81E+3nMAssay Description:Binding affinity for human Dopamine receptor D3 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  2.82E+3nMAssay Description:Binding affinity towards human dopamine receptor D2 was determined by using [3H]spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  3.74E+3nMAssay Description:Binding affinity towards cloned human Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  3.74E+3nMAssay Description:Binding affinity for human Dopamine receptor D2 expressed in CHO K1 transfected cells using [3H]-Spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  4.01E+3nMAssay Description:Binding affinity of the compound at 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  4.70E+3nMAssay Description:Displacement of [3H] Spiperone from human D3 receptor expressed in CHO cells by competitive radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Universit£

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  6.30E+3nMAssay Description:Affinity for Dopamine receptor D2 using [3H]YM-09151-2 was carried out on bovine retinal membrane preparations (low-affinity)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
Universit£

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi: >1.00E+4nMAssay Description:Affinity for Dopamine receptor D1 using [3H]SCH-23390 was carried out on bovine retinal membrane preparationsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
Universit£

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataKi:  1.83E+4nMAssay Description:Affinity for Dopamine receptor D2 using [3H]-YM-09151-2 was carried out on bovine striatal membrane preparationsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataEC50:  6.90nMAssay Description:Agonist activity at human D4R expressed in HEK293 cells by calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataEC50:  17nMAssay Description:Agonist activation of human dopamine receptor stimulating mitogenesis in Dopamine receptor D4-transfected CHO pro-5 cells using [3H]-thymidine as rad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataEC50:  8.30nMAssay Description:Agonist activity at human D4.4 receptor in HEK293 cells coexpressing Galphaqo5 by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant D2 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander-Universit£T Erlangen-N£Rnberg

Curated by ChEMBL
LigandPNGBDBM50058225(CHEMBL45244 | N-((4-(2-cyanophenyl)piperazin-1-yl)...)
Affinity DataEC50:  8.30nMAssay Description:Activity at human recombinant D4.4 receptor expressed in HEK293 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed