BDBM50059480 3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::CHEMBL316342

SMILES COC(=O)C1C2CCC(CC1c1ccc(Cl)c(Cl)c1)O2

InChI Key InChIKey=DHXANQGCRAVCSQ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50059480   

TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  56nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter (DAT) in monkey caudate-putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  2.86E+3nMAssay Description:Inhibition of [3H]citalopram binding to the serotonin transporter (5-HT) in monkey caudate-putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  31nMAssay Description:Inhibition of [3H]citalopram binding to the serotonin transporter (5-HT) in monkey caudate-putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine transporter (DAT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Macaca fascicularis)
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  64.5nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter (SERT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Organix

Curated by ChEMBL
LigandPNGBDBM50059480(3-(3,4-Dichloro-phenyl)-8-oxa-bicyclo[3.2.1]octane...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporter (DAT) in monkey caudate-putamen.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed