BDBM50061611 CHEMBL3394069::US9321756, 16

SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NC4CCCC4)n3)c2c1

InChI Key InChIKey=LYSVYDGAEVIKAF-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50061611   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  12.4nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  21.1nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  5.07nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  21nMAssay Description:Inhibition of full length recombinant PIM2 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  12nMAssay Description:Inhibition of full length recombinant PIM1 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  3.09E+3nMAssay Description:Inhibition of PIM2 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  111nMAssay Description:Inhibition of PIM1 in human U2OS cells assessed as phosphorylation of BADMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50061611(CHEMBL3394069 | US9321756, 16)
Affinity DataIC50:  5nMAssay Description:Inhibition of full length recombinant PIM3 (unknown origin) using biotinylated-BAD peptide as substrate assessed as phosphorylation at serine 112 aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed