BDBM50065308 (Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one::(Z)-ethyl 2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrole-3-carboxylate::2,4-Dimethyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester::CHEMBL86943

SMILES CCOC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccccc23)c1C

InChI Key InChIKey=PMUJUSJUVIXDQC-LCYFTJDESA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50065308   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Mus musculus)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  70nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of PDGFChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of EGFChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of FGFR1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University Of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  760nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50065308((Z )-3-[(2,4-dimethyl-3-(ethoxycarbonyl)pyrrol-5-y...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of bPDGFR in human PAC1 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed