BDBM50067311 4-{(E)-2-[({[2,4-Dichloro-3-(2-methyl-quinazolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-carbamoyl]-vinyl}-N-methyl-benzamide::CHEMBL298463

SMILES CNC(=O)c1ccc(\C=C\C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4cnc(C)nc34)c2Cl)cc1

InChI Key InChIKey=FRQLTBAERTVIAL-NTEUORMPSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50067311   

TargetB2 bradykinin receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067311(4-{(E)-2-[({[2,4-Dichloro-3-(2-methyl-quinazolin-8...)
Affinity DataIC50:  56nMAssay Description:Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Cavia porcellus)
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067311(4-{(E)-2-[({[2,4-Dichloro-3-(2-methyl-quinazolin-8...)
Affinity DataIC50:  110nMAssay Description:Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067311(4-{(E)-2-[({[2,4-Dichloro-3-(2-methyl-quinazolin-8...)
Affinity DataIC50:  59nMAssay Description:Concentration required to inhibit specific binding of [3H]BK (1.2 nM) to A-431 cells (human epidermoidcarcinoma) which express Bradykinin receptor B2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed