BDBM50067869 CHEMBL139430::N*6*-Methyl-N*6*-naphthalen-2-yl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

SMILES CN(c1ccc2ccccc2c1)c1ccc2nc(N)nc(N)c2n1

InChI Key InChIKey=RNUDCJLFNJKMQC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50067869   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067869(CHEMBL139430 | N*6*-Methyl-N*6*-naphthalen-2-yl-py...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against dihydrofolate reductase(DHFR) from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067869(CHEMBL139430 | N*6*-Methyl-N*6*-naphthalen-2-yl-py...)
Affinity DataIC50:  9.90nMAssay Description:Inhibitory activity against dihydrofolate reductase(DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067869(CHEMBL139430 | N*6*-Methyl-N*6*-naphthalen-2-yl-py...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against dihydrofolate reductase(DHFR) from Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed