BDBM50067873 CHEMBL138419::N*6*-Naphthalen-2-yl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

SMILES Nc1nc(N)c2nc(Nc3ccc4ccccc4c3)ccc2n1

InChI Key InChIKey=LAFXRCGOBLGDFM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50067873   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067873(CHEMBL138419 | N*6*-Naphthalen-2-yl-pyrido[3,2-d]p...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067873(CHEMBL138419 | N*6*-Naphthalen-2-yl-pyrido[3,2-d]p...)
Affinity DataIC50:  3.19E+3nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using 9 uM DHFA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067873(CHEMBL138419 | N*6*-Naphthalen-2-yl-pyrido[3,2-d]p...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067873(CHEMBL138419 | N*6*-Naphthalen-2-yl-pyrido[3,2-d]p...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed