BDBM50067874 CHEMBL139188::N*6*-Phenyl-pyrido[3,2-d]pyrimidine-2,4,6-triamine

SMILES Nc1nc(N)c2nc(Nc3ccccc3)ccc2n1

InChI Key InChIKey=LKOOXGFMGXIJFK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50067874   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against dihydrofolate reductase (DHFR) from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  1.53E+3nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using 9 uM DHFA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  430nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50067874(CHEMBL139188 | N*6*-Phenyl-pyrido[3,2-d]pyrimidine...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed