BDBM50072702 9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::9-chloro-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline::CHEMBL64123

SMILES CC1=CC(C)(C)Nc2ccc-3c(COc4ccc(Cl)cc-34)c12

InChI Key InChIKey=GZULQASDNRKTNT-UHFFFAOYSA-N

Data  3 KI  1 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50072702   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  3.60nMAssay Description:Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataKi:  13nMAssay Description:Binding affinity at human progesterone receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  36nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  171nMAssay Description:Antagonistic activity at human progesterone receptor in CV-1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataIC50:  788nMAssay Description:Inhibition of antagonist activity towards Androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  2.19E+3nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072702(9-Chloro-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-az...)
Affinity DataEC50:  45nMAssay Description:Antagonist activity against hPR (human progesterone receptor) compared to that of progesterone (100%)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed