BDBM50075778 4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-1H-imidazol-4-yl]-pyridine::4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)-3H-imidazol-4-yl]-pyridine::CHEMBL17370

SMILES CSc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1

InChI Key InChIKey=ZPXPEKQMLOAPLT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50075778   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  117nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  490nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  490nMAssay Description:Binding affinity towards human glucagon receptor in absence of Mg2+ expressed as IC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  120nMAssay Description:Binding affinity towards human Mitogen-activated protein kinase p38 expressed as IC50More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  117nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  580nMAssay Description:Inhibitory activity against interleukin-1(IL-1) synthesis, using intact human monocytesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50075778(4-[5-(4-Fluoro-phenyl)-2-(4-methylsulfanyl-phenyl)...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article