BDBM50076296 (4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-phenyl)-1,2,4,5-tetrahydro-6-oxa-1-aza-chrysen-3-one::CHEMBL286158

SMILES C[C@H]1C(=O)C(C)(C)Nc2ccc3-c4ccccc4O[C@@H](c4cccc(c4)C(F)(F)F)c3c12

InChI Key InChIKey=FZORYLRILGENBG-FATZIPQQSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50076296   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076296((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...)
Affinity DataKi:  123nMAssay Description:Compound was evaluated for its binding affinity against baculovirus expressed Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076296((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...)
Affinity DataKi:  250nMAssay Description:Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076296((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...)
Affinity DataKi:  807nMAssay Description:Binding affinity against baculovirus expressed human androgen receptor (hAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076296((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...)
Affinity DataEC50:  16nMAssay Description:Compound was tested for agonistic activity by cotransfection assay against human Progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50076296((4R,5S)-2,2,4-Trimethyl-5-(3-trifluoromethyl-pheny...)
Affinity DataEC50:  63nMAssay Description:Agonistic activity by cotransfection assay against human Progesterone receptor in T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed