BDBM50086442 CHEMBL3426233::US10266537, Compound 121

SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nn(C4CCN(CC4)C(=O)C=C)c4ncnc(N)c34)cc2C(F)(F)F)CC1

InChI Key InChIKey=VRCBGBBYFHLJRE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50086442   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50:  15nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1 [T315I](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50:  133nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src [1-530](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50:  15nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50:  52nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50:  22nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50086442(CHEMBL3426233 | US10266537, Compound 121)
Affinity DataIC50:  2nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent