BDBM50086542 4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-quinolin-6-yl)-thiophene-2-carbonitrile::4-(2,2,4,4-tetramethyl-3-oxo-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carbonitrile::CHEMBL131681

SMILES CC1(C)Nc2ccc(cc2C(C)(C)C1=O)-c1csc(c1)C#N

InChI Key InChIKey=ZWGPOLYPUOBDPY-UHFFFAOYSA-N

Data  2 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50086542   

TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataKi:  12nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataIC50:  1.10E+3nMAssay Description:Cross-reactivity as binding to human androgen receptor (hAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataIC50:  2.70E+3nMAssay Description:Cross-reactivity as binding to human mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataIC50:  14nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataEC50:  1.19E+3nMAssay Description:Human progesterone receptor (hPR) agonist activity expressed in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086542(4-(2,2,4,4-Tetramethyl-3-oxo-1,2,3,4-tetrahydro-qu...)
Affinity DataIC50:  900nMAssay Description:Cross-reactivity as binding to human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed