BDBM50086546 4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thiophene-2-carbonitrile::4-(2,2,4-trimethyl-1,2-dihydroquinolin-6-yl)thiophene-2-carbonitrile::CHEMBL335992

SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1csc(c1)C#N

InChI Key InChIKey=QASVQWYKHBDCLY-UHFFFAOYSA-N

Data  2 KI  5 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50086546   

TargetProgesterone receptor(Homo sapiens (Human))
Scientific Computing

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [3H]progesterone from Progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Scientific Computing

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataKi:  3.5nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataIC50:  2.05E+3nMAssay Description:Cross-reactivity as binding to human mineralocorticoid receptor (hMR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Scientific Computing

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataIC50:  106nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataIC50:  2.60E+3nMAssay Description:Cross-reactivity as binding to human glucocorticoid receptor (hGR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Scientific Computing

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataEC50:  245nMAssay Description:Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Scientific Computing

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataEC50:  1.80E+3nMAssay Description:Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Scientific Computing

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity against human progesterone receptor (hPR) using cotransfection assay in CV-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50086546(4-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-thio...)
Affinity DataIC50:  494nMAssay Description:Cross-reactivity as binding to human androgen receptor (hAR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed