BDBM50098275 2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-phenyl-pent-4-ynoic acid::CHEMBL10671

SMILES CSc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)NC(CC#Cc1ccccc1)C(O)=O

InChI Key InChIKey=UMBHCIONUFCHIP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50098275   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098275(2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-p...)
Affinity DataIC50:  6nMpH: 7.4Assay Description:Inhibitory activity against matrix metalloproteinase-2 (MMP-2) in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098275(2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-p...)
Affinity DataIC50:  3.40E+3nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloproteinase-3 (MMP-3) (at pH 7.4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50098275(2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-p...)
Affinity DataIC50:  15.8nMAssay Description:Inhibitory activity against recombinant human matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50098275(2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-p...)
Affinity DataIC50:  631nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloproteinase-1 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM50098275(2-(4'-Methylsulfanyl-biphenyl-4-sulfonylamino)-5-p...)
Affinity DataIC50:  16nMpH: 7.4Assay Description:Inhibitory activity against human matrix metalloproteinase-13 in quenched fluorescence assay at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed