BDBM50098382 (1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid::(1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phosphonic acid(NE58051,homorisedronate)::1-hydroxy-3-(pyridin-3-yl)propane-1,1-diyldiphosphonic acid::3-(3-Hydroxy-3,3-bis-phosphono-propyl)-pyridinium::3-(3-hydrogen phosphonato-3-hydroxy-3-phosphonatopropyl)pyridin-1-ium::3-(3-pyridyl)-1-hydroxy-propane-1,1-bisphosphonate::CHEMBL293522

SMILES OC(CCc1cccnc1)(P(O)(O)=O)P(O)(O)=O

InChI Key InChIKey=ILROXFQHACCDLA-UHFFFAOYSA-N

Data  3 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50098382   

TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataKi:  78nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataKi:  363nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataKi:  510nMAssay Description:Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human FPPS using pre-incubation of compound with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  5.37E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  337nMAssay Description:Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibitory activity against farnesyl Pyrophosphate Synthase was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  4.10E+5nMAssay Description:Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  2.93E+3nMAssay Description:Inhibitory activity against the human recombinant FPPSase(Farnesyl diphosphate) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50098382((1-Hydroxy-1-phosphono-3-pyridin-3-yl-propyl)-phos...)
Affinity DataIC50:  363nMAssay Description:Inhibition of human FPPS in absence of pre-incubation of compound with enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed