BDBM50098928 3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylamine::CHEMBL8088

SMILES NC1=NC(Cc2ccccc12)c1ccc(F)cc1

InChI Key InChIKey=KWMGDJOVVNCHIR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50098928   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098928(3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098928(3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
Affinity DataIC50:  4.00E+4nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098928(3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
Affinity DataIC50:  5.50E+3nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed