BDBM50099903 4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulfanyl-thiophene-2-carboxamidine::CHEMBL29205

SMILES COc1cccc(c1)-c1csc(n1)-c1cc(sc1SC)C(N)=N

InChI Key InChIKey=HFUGBKCICWUZIJ-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50099903   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  115nMAssay Description:Inhibitory activity against serine protease urokinase-type plasminogen activator (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1s subcomponent(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  470nMAssay Description:In vitro binding affinity towards human Complement C1s subcomponentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  860nMAssay Description:Inhibitory activity of the compound against TrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory activity of the compound against tissue plasminogen activatorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi:  6.90E+3nMAssay Description:Inhibitory activity of the compound against plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory activity of the compound against Thrombin (no observable inhibition at this screening concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
3-Dimensional Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099903(4-[4-(3-Methoxy-phenyl)-thiazol-2-yl]-5-methylsulf...)
Affinity DataKi: >3.00E+4nMAssay Description:Inhibitory activity of the compound against Serine protease chymotrypsin (no observable inhibition at this screening concentration)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed