BDBM50102258 (S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-pentanedioic acid::2-[3-(1,3-Dicarboxy-propyl)-ureido]-pentanedioic acid::CHEMBL46005

SMILES OC(=O)CC[C@H](NC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O

InChI Key InChIKey=SOAPXKSPJAZNGO-WDSKDSINSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50102258   

TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Binding affinity PSMA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Inhibition of human GCPII expressed in CHO cells assessed as accumulation of glutamate using NAAG as substrate by e Amplex Red glutamic acid assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN-acetylated-alpha-linked acidic dipeptidase 2(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:In vitro inhibitory activity against human Glutamate carboxypeptidase II by using fluorescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataIC50:  47nMAssay Description:Inhibition of PSMA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of GCPII (unknown origin) expressed in DU-145 cells after 2 hrs by Amplex red reagent based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity of the compound against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 microMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed