BDBM50103246 10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL99046

SMILES COc1cccc2OC(c3ccccc3)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=JLKOGSSZSBFPNY-UHFFFAOYSA-N

Data  8 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50103246   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity for glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  1.68E+3nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi:  2.66E+3nMAssay Description:Binding affinity for androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity for mineralocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity for androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity for progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50:  123nMAssay Description:Transcriptional repression activity in HEP G2 cells expressing glucocorticoid receptor compared to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50:  164nMAssay Description:Glucocorticoid-induced aromatase activity in human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50:  30nMAssay Description:Transcriptional repression of IL-1 stimulated IL-6 expression in native cells compared to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50:  51nMAssay Description:Repression activity of GR ligand with interleukin-6 receptor in native cell assay using dexamethasone was determined as maximal potencyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50103246(10-Methoxy-2,2,4-trimethyl-5-phenyl-2,5-dihydro-1H...)
Affinity DataIC50:  300nMAssay Description:Transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed