BDBM50105088 1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-ylmethyl-1,3,8-triaza-spiro[4.5]decan-4-one::8-Benzo[1,2,5]thiadiazol-5-ylmethyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL325750

SMILES O=C1NCN(c2ccccc2)C11CCN(Cc2ccc3nsnc3c2)CC1

InChI Key InChIKey=QHTFQZNDPJWDIE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50105088   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  4.25E+3nMAssay Description:Inhibition of alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  4.12E+3nMAssay Description:Inhibition of ligand binding to human delta opioid receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  4.12E+3nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  104nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  25nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  29nMAssay Description:Binding affinity against mu opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  104nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  123nMAssay Description:Inhibition of human dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human dopamine receptor D3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of human dopamine receptor D4.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM50105088(1-Phenyl-8-[1,3,4]thiadiazolo[3,4-a]pyridazin-6-yl...)
Affinity DataIC50:  758nMAssay Description:Inhibition of human ORL1 orphanin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed