BDBM50106017 CHEMBL421009::N-Hydroxy-2-methyl-3-[4-(3,4,5-trimethoxy-phenoxy)-benzenesulfonyl]-propionamide

SMILES COc1cc(Oc2ccc(cc2)S(=O)(=O)CC(C)C(=O)NO)cc(OC)c1OC

InChI Key InChIKey=LUOBAMXDTNOZAD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50106017   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  4.10E+4nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  430nMAssay Description:Inhibition against Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of TACE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  3.98E+4nMAssay Description:Inhibition of TACE (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  4.10E+4nMAssay Description:Displacement of 0.5 nM [3H]WIN-35248 from Dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50106017(CHEMBL421009 | N-Hydroxy-2-methyl-3-[4-(3,4,5-trim...)
Affinity DataIC50:  6.5nMAssay Description:Concentration required to inhibit the release of tumor necrosis factor -alpha (TNF-alpha) in THP-1 cellular assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed