BDBM50110766 5-Biphenyl-4-yl-6-ethyl-pyrimidine-2,4-diamine::CHEMBL279986

SMILES CCc1nc(N)nc(N)c1-c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=PMSUAONSGCBMTC-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50110766   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Università

Curated by ChEMBL
LigandPNGBDBM50110766(5-Biphenyl-4-yl-6-ethyl-pyrimidine-2,4-diamine | C...)
Affinity DataKi:  90nMAssay Description:Inhibition constant against Plasmodium falciparum dihydrofolate reductaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Università

Curated by ChEMBL
LigandPNGBDBM50110766(5-Biphenyl-4-yl-6-ethyl-pyrimidine-2,4-diamine | C...)
Affinity DataKi:  188nMAssay Description:Inhibition of the wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Università

Curated by ChEMBL
LigandPNGBDBM50110766(5-Biphenyl-4-yl-6-ethyl-pyrimidine-2,4-diamine | C...)
Affinity DataKi:  421nMAssay Description:Inhibition of the S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Università

Curated by ChEMBL
LigandPNGBDBM50110766(5-Biphenyl-4-yl-6-ethyl-pyrimidine-2,4-diamine | C...)
Affinity DataKi:  730nMAssay Description:Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
Università

Curated by ChEMBL
LigandPNGBDBM50110766(5-Biphenyl-4-yl-6-ethyl-pyrimidine-2,4-diamine | C...)
Affinity DataIC50:  4.40E+3nMAssay Description:Antiplasmodial activity (IC50) against Plasmodium falciparum Clone with mutant enzyme C59R+S108N- pfDihydrofolate reductase (K1CB1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed