BDBM50113483 CHEMBL3604612

SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1cnc(Cl)c(NC(=O)c2cccc(Cl)c2)c1

InChI Key InChIKey=FNHRFDMOXHKTPK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50113483   

TargetSmoothened homolog(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50113483(CHEMBL3604612)
Affinity DataIC50:  10nMAssay Description:Inhibition of human Smo expressed in human U2OS cells assessed as reduction in BODIPY-cyclopamine fluorescence signaling by competitive displacement ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Soochow University

Curated by ChEMBL
LigandPNGBDBM50113483(CHEMBL3604612)
Affinity DataIC50:  980nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as reduction in luminescence signaling by kinase-Glo plus luminescent kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50113483(CHEMBL3604612)
Affinity DataIC50:  41nMAssay Description:Inhibition of SMO in mouse NIH/3T3 cells assessed as inhibition of SAG-induced hedgehog-mediated luminescence signaling by GRE-luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed