BDBM50122318 BMS-911543
SMILES CCn1c(cc2c1nc(Nc1cc(C)n(C)n1)c1ncn(C)c21)C(=O)N(C1CC1)C1CC1
InChI Key InChIKey=JCINBYQJBYJGDM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50122318
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2/Tyrosine-protein kinase JAK3(Homo sapiens (Human))
Genentech
Curated by ChEMBL
Genentech
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of JAK in human BEAS-2B cells assessed as reduction in IL13-induced STAT6 phosphorylation incubated for 1 hr followed by IL13 addition and...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of JAK2 in human SET2 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by ChEMBL
Bristol-Myers Squibb R & D
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of recombinant TYK2 (unknown origin) by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of recombinant JAK3 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant JAK1 (unknown origin) using 5-FAM-KKKKEEIYFFFG-OH substrate and ATP incubated for 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Bristol-Myers Squibb R & D
Curated by ChEMBL
Bristol-Myers Squibb R & D
Curated by ChEMBL
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of JAK2 in mouse BAF3 cells assessed as reduction in STAT5 phosphorylation incubated for 2 hrs by Western blot methodMore data for this Ligand-Target Pair