BDBM50124593 5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL8394

SMILES CSc1cccc2OC(CC=C)c3c(ccc4NC(C)(C)C=C(C)c34)-c12

InChI Key InChIKey=XTULGNRZXMHXPU-UHFFFAOYSA-N

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50124593   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124593(5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihy...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]-Dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124593(5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihy...)
Affinity DataKi:  2.46E+3nMAssay Description:Binding affinity towards testosterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124593(5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihy...)
Affinity DataKi:  4.74E+3nMAssay Description:Displacement of [3H]-progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124593(5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihy...)
Affinity DataEC50:  18nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124593(5-Allyl-2,2,4-trimethyl-10-methylsulfanyl-2,5-dihy...)
Affinity DataEC50:  123nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed