BDBM50124606 5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL267940

SMILES CC1=CC(C)(C)Nc2ccc-3c(C(CC=C)Oc4cccc(C=C)c-34)c12

InChI Key InChIKey=CPUIRDMVUBPAPK-UHFFFAOYSA-N

Data  3 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50124606   

TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity towards human glucocorticoid receptor (GR) was determined using [3H]-Dexamethasone as radioligand in SF-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  239nMAssay Description:Binding affinity towards testosterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataKi:  435nMAssay Description:Displacement of [3H]-progesterone from human Progesterone receptor AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  17nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  90nMAssay Description:Inhibition of conconavalin A stimulated rat splenocyte proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50124606(5-Allyl-2,2,4-trimethyl-10-vinyl-2,5-dihydro-1H-6-...)
Affinity DataEC50:  12nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed