BDBM50126143 Epacadostat::INCB-024360
SMILES NS(=O)(=O)NCCNc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O
InChI Key InChIKey=FBKMWOJEPMPVTQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 100 hits for monomerid = 50126143
Affinity DataKi: 2.17E+4nMAssay Description:Uncompetitive inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as assessed as inhibition constant using varying ...More data for this Ligand-Target Pair
Affinity DataKi: 2.17E+4nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human N-terminus IDO1 expressed in Escherichia coli assessed as N-formylkynurenine formation using L-tryptophan as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of IDO1 in IFN-gamma/LPS-stimulated human whole blood assessed as decrease in kynurenine levels preincubated for 15 mins followed by IFN-g...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of human N-terminal His-tagged IDO1 expressed in Escherichia coli using D-Trp as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant IDO1 assessed as reduction in kynurenine production using L-tryptophan incubated for 60 mins by Ehrlich's reagent bas...More data for this Ligand-Target Pair
Affinity DataEC50: 8.70nMAssay Description:Inhibition of human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine production after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCsMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of concanavalin A stimulated T-cell proliferation in human PBMCsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of IDO1 in recombinant human IFNgamma and LPS-induced human HeLa assessed as reduction in kynurenine production incubated for 2 days by sp...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human OCI-AML2 cells assessed as reduction in kynurenine productionMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human IDO1 expressed in HEK293/MSR cells assessed as reduction in kynurenine production incubated fro 2 daysMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of IDO1 (unknown origin) using D-tryptophan as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of human IDO1 using D-Trp as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human GST-tagged IDO1 (1 to 404 residues) using D-Tryptophan as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of IFN-gamma-stimulated IDO1 activity in human HeLa cells using L-tryptophan as substrate after 48 hrs by microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of N-terminal His-tagged human recombinant IDO1 expressed in Escherichia coli using D-tryptophan as substrate by methylene blue/ascorbate ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.45E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 242nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 73nMAssay Description:Inhibition of human N-terminal GST-tagged IDO1 expressed in Escherichia coli Rosetta(DE3) pLysS using L-tryptophan as substrate measured after 1 hr b...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human A375 cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataKd: 3.46E+3nMAssay Description:Binding affinity to NT650-NHS fluorophore-labeled recombinant human N-terminal His-tagged IDO1 expressed in Escherichia coli measured after 10 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of IDO1 in interferon-gamma-induced human SKOV3 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate measured af...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human IDO1 expressed in HEK293 cells assessed as N-formylkynurenine formation by measuring kynurenine level incubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of mouse IDO2 expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+4nMAssay Description:Inhibition of human TDO expressed in human T-REx cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate after 20 hrsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Materia Medica (Simm)
Curated by ChEMBL
Shanghai Institute Of Materia Medica (Simm)
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells using L-tryptophan as substrate incubated for 30 mins by methylene blue...More data for this Ligand-Target Pair
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of C-terminal His6-tagged human IDO2 (14 to 420 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of ...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production incubated for 18 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of N-terminal His-tagged human IDO1 expressed in Escherichia coli assessed as reduction in conversion of D-tryptophan to N-formyl kynureni...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of IFN-gamma stimulated IDO1 in human HeLa cells assessed as reduction in formation of kynurenine incubated for 48 hrs in presence of IFNg...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynuren...More data for this Ligand-Target Pair
Affinity DataIC50: 6.45E+4nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 (DE3) assessed as reduction in conversion of L-tryptophan to N-formyl kynureni...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of human TDO transfected in HEK293 cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 12 h...More data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of IDO1 in IFN-gamma/LPS stimulated human THP-1 cells assessed as reduction in kynurenine production after 24 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production incubated for 24 hrs relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate incubated for 48 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged human TDO expressed in Escherichia coli expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant N-terminal His-tagged human IDO1 expressed in Escherichia coli assessed as reduction in N-formylkynurenine formation using ...More data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Inhibition of N-terminal His-tagged human IDO2 expressed in Escherichia coli expression systemMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Inhibition of IFNgamma-stimulated IDO1 in human HeLa cellsMore data for this Ligand-Target Pair