BDBM50128281 18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triazahexacyclo[19.6.1.17,14.02,6.08,13.022,27]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione; methane sulphonic acid salt::CHEMBL432130

SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21

InChI Key InChIKey=ZCBUQCWBWNUWSU-SFHVURJKSA-N

Data  11 IC50

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50128281   

TargetProtein kinase C eta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  52nMAssay Description:Inhibition of Protein kinase C etaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  360nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C zeta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of purified mammalian brain [Ca(2+)]/Calmodulin dependent kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  250nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  600nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  320nMAssay Description:Inhibition of purified rat brain protein kinase C (RB-PKC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50128281(18-dimethylaminomethyl-(18S)-17-oxa-4,14,21-triaza...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed