BDBM50130248 CHEMBL79004::N-(6-Chloro-9H-beta-carbolin-8-yl)-nicotinamide::PS-1145
SMILES Clc1cc(NC(=O)c2cccnc2)c2[nH]c3cnccc3c2c1
InChI Key InChIKey=JZRMBDHPALEPDM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50130248
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylaton assay.More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibition of IKK-beta in the presence of 5uM ATPMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PIM1 in the presence of 20uM ATPMore data for this Ligand-Target Pair
TargetO94806/P05129/P05771/P17252/P24723/P41743/Q02156/Q04759/Q05513/Q05655/Q15139(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against protein kinase C.More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of IKK-beta by tome resolved fluorescence assayMore data for this Ligand-Target Pair
TargetNF-kappa-B essential modulator(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Inhibition of GST-IkB phosphorylation by TNF-alpha stimulated HeLa cell lysate (IP-IKKgamma)More data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against protein kinase A.More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
University Of Dundee
Curated by ChEMBL
University Of Dundee
Curated by ChEMBL
Affinity DataIC50: 880nMAssay Description:Inhibition of PIM3 in the presence of 20uM ATPMore data for this Ligand-Target Pair