BDBM50131806 CHEMBL3634339

SMILES COc1cnc(cn1)C(=O)Nc1cc(ccn1)[C@@]1(C)N=C(N)CO[C@@H]1F

InChI Key InChIKey=MFDHEHSRVZGAHP-JKSUJKDBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50131806   

TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131806(CHEMBL3634339)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by sandw...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50131806(CHEMBL3634339)
Affinity DataIC50:  3.47E+3nMAssay Description:Inhibition of BACE1 (unknown origin) using APP Swedish mutant harboring Lys-Met/Asn-Leu mutation in beta-secretase cleavage site as substrate by FRET...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed