BDBM50132310 20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[24.6.1.17,14.02,6.08,13.027,32]tetratriaconta-1(33),2(6),7(34),8(13),9,11,27(32),28,30-nonaene-3,5-dione::CHEMBL103055

SMILES CCN1CCOCCn2cc(C3=C(C(=O)NC3=O)c3cn(CCOCC1)c1ccccc31)c1ccccc21

InChI Key InChIKey=SFDFKLDQKSPRHB-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50132310   

TargetProtein kinase C alpha type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Protein kinase C alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  240nMAssay Description:Inhibition of CDK1/cyclinBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  75nMAssay Description:Inhibition of Protein kinase C epsilonMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Cyclin-dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  1.41E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Insulin receptor kinase-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Protein kinase C gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mitogen-activated protein kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Protein kinase C deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha/beta/delta/gamma(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  780nMAssay Description:Inhibition of PKC-beta II mediated IL-8 release from HEK293 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PKC-beta II mediated IL-8 release from HEK293 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha/delta/epsilon/gamma-1/gamma-2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Casein kinase IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  18nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50132310(20-ethyl-17,23-dioxa-4,14,20,26-tetraazahexacyclo[...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed