BDBM50137278 2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::2-(2,5-dichlorophenylsulfonyl)-N,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::CHEMBL424130

SMILES ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl

InChI Key InChIKey=QMIAXILIKVOPKK-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50137278   

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of matrix metalloproteinase-9 (MMP-9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-26(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of MMP-26 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  170nMAssay Description:Inhibition of matrix metalloproteinase-12 (MMP-12)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  1.79E+3nMAssay Description:Inhibition of matrix metalloproteinase-15 (MMP-15)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of matrix metalloproteinase-7 (MMP-7)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-26(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  7.90E+3nMAssay Description:Inhibition of matrix metalloproteinase-26 (MMP-26)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of matrix metalloproteinase-16 (MMP-16)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  853nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of MMP-1 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  853nMAssay Description:Inhibition of MMP-2 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrilysin(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  2.14E+4nMAssay Description:Inhibition of MMP-7 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of MMP-9 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  170nMAssay Description:Inhibition of MMP-12 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  4.61E+3nMAssay Description:Inhibition of MMP-14 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  1.79E+3nMAssay Description:Inhibition of MMP-15 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of MMP-16 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50137278(2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4...)
Affinity DataIC50:  4.61E+3nMAssay Description:Inhibition of matrix metalloproteinase-14 (MMP-14)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed