BDBM50137583 3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-propyl}-4,5,6,7-tetrahydro-1H-indol-2-yl)-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid methylamide::CHEMBL56109

SMILES CNS(=O)(=O)c1ccc2NC(=O)\C(=C/c3[nH]c4CCCCc4c3CCCN3CCN(CCO)CC3)c2c1

InChI Key InChIKey=WWSWQMMEPXHAON-NKFKGCMQSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50137583   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against Fibroblast growth factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against cellular Src protein tryrosine kinase using the actin ring assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against Yes tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against Fyn tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibitory activity against PDGFRbeta tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Sugen

Curated by ChEMBL
LigandPNGBDBM50137583(3-[1-(3-{3-[4-(2-Hydroxy-ethyl)-piperazin-1-yl]-pr...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed