BDBM50149797 2-Methyl-4-o-tolylethynyl-thiazole::CHEMBL181915

SMILES Cc1nc(cs1)C#Cc1ccccc1C

InChI Key InChIKey=XDQBEOSJZSBVGG-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50149797   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50149797(2-Methyl-4-o-tolylethynyl-thiazole | CHEMBL181915)
Affinity DataKi:  51nMAssay Description:Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50149797(2-Methyl-4-o-tolylethynyl-thiazole | CHEMBL181915)
Affinity DataIC50:  15nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed