BDBM50149802 2-Methyl-4-m-tolylethynyl-thiazole::2-methyl-4-(m-tolylethynyl)thiazole::CHEMBL182950

SMILES Cc1nc(cs1)C#Cc1cccc(C)c1

InChI Key InChIKey=LYHRSGPNRBPYDG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50149802   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50149802(2-Methyl-4-m-tolylethynyl-thiazole | 2-methyl-4-(m...)
Affinity DataKi:  10nMAssay Description:Displacement by compound of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50149802(2-Methyl-4-m-tolylethynyl-thiazole | 2-methyl-4-(m...)
Affinity DataIC50:  82.6nMAssay Description:Activity in agonist-induced phosphoinositide hydrolysis in CHO cells expressing mGluR5aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50149802(2-Methyl-4-m-tolylethynyl-thiazole | 2-methyl-4-(m...)
Affinity DataIC50:  2nMAssay Description:In vitro potency against human recombinant mGlu5 receptor was determined by [Ca2+] flux assay using glutamate as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed