BDBM50151297 CHEMBL3771056

SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(Cl)c2)nc2c1C=CCN=C2c1ccccc1

InChI Key InChIKey=JCXJUPGTOXNJCK-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50151297   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL

LigandBDBM50151297(CHEMBL3771056)Copy SMILESCopy InChI

Affinity DataIC50:  5nMAssay Description:Modulation of gamma-secretase activity (unknown origin) assessed as amyloid-beta(1-42) production by ELISAMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI