BDBM50151363 4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiazol-2-ylamine::4-(3-chlorophenyl)-5-(1,5-naphthyridin-2-yl)thiazol-2-amine::CHEMBL365663

SMILES Nc1nc(c(s1)-c1ccc2ncccc2n1)-c1cccc(Cl)c1

InChI Key InChIKey=JVXFJMXCRSAZFH-UHFFFAOYSA-N

Data  11 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50151363   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant Activin A receptor type II-like kinase (ALK5) expressed in baculovirus/Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to Activin A receptor type II-like kinase (ALK5) in fluorescence polarization binding assay; Range is (0.020-0.026)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Stimulation of Transforming growth factor beta receptor I kinase in HepG2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  13nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase(Cryptosporidium parvum (strain Iowa II))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cryptosporidium parvum Iowa II mitogen-activated protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cryptosporidium parvum Iowa II calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF handsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division control protein 28, putative(Cryptosporidium parvum (strain Iowa II))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cryptosporidium parvum Iowa II cell division control protein 28More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50:  10nMAssay Description:Inhibition of TGFbeta-induced ALK5 in human HepG2 cells pretreated for 30 mins followed by TGFbeta stimulation measured after overnight incubation by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cryptosporidium parvum Iowa II calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF handsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCgd2_1060 protein(Cryptosporidium parvum)
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cryptosporidium parvum calcium-dependent protein kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCgd5_820 protein(Cryptosporidium parvum)
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50151363(4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF handsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed