BDBM50151910 3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonitrile::CHEMBL187107

SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N

InChI Key InChIKey=NNUSSUPIQZLYJW-UHFFFAOYSA-N

Data  5 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50151910   

TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from glutamate 5 receptor of rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataKi:  14nMAssay Description:Ability to displace [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from binding to metabotropic glutamate receptor 5 in rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataIC50:  4nMAssay Description:In vitro functional activity measured by changes in cytosolic [Ca2+] concentrations against rat metabotropic glutamate receptor 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataIC50:  3.90nMAssay Description:Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration towards human glutamate receptor 5 in calcium flux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50151910(3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...)
Affinity DataIC50:  4nMAssay Description:Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonistMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed