BDBM50153040 3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazole::CHEMBL363228

SMILES Cc1onc(-c2ccc(Cl)o2)c1-c1ccccc1

InChI Key InChIKey=IPAVFMUBTIUYBW-UHFFFAOYSA-N

Data  14 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50153040   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 1 in human whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  500nMAssay Description:Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  3.90E+4nMAssay Description:Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human monocyte COX2 by whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universit£

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of ovine COX1 by peroxidase activity-based colorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of COX-2 in human whole blood assessed as inhibition of LPS-induced plasma PGE2 level by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  500nMAssay Description:Inhibition of COX-1 in human whole blood assessed as inhibition of serum TXB2 level after 1 hr by radioimmunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of COX-1 (unknown origin) in platelet rich plasma assessed as inhibition of collagen-induced TXB2 formation incubated for 5 mins prior to ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of COX-1 (unknown origin) in platelet rich plasma assessed as inhibition of arachidonic acid-induced TXB2 formation incubated for 5 mins p...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human platelet COX1 by whole blood assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Thomas Jefferson University

Curated by ChEMBL
LigandPNGBDBM50153040(3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant ovine COX2 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed