BDBM50154943 CHEMBL3775576

SMILES CNC(=O)c1ccc2[nH]nc(Cc3ccc4n(C)ncc4c3)c2c1

InChI Key InChIKey=ZKGWDQMQMQRGLJ-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50154943   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  240nMAssay Description:Inhibition of 5HT2A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  260nMAssay Description:Inhibition of PASK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  340nMAssay Description:Inhibition of CDK8-dependent WNT signalling in human LS174T cells in absence of WNT ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  710nMAssay Description:Inhibition of CDK8-dependent WNT signalling in human LS174T cells in presence of WNT3a ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  10nMAssay Description:Displacement of dye-labeled ATP competitive probe from recombinant human CDK8/Cyclin C incubated for 20 mins by Alexa647 probe-based FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  65nMAssay Description:Inhibition of CDK8 (unknown origin) expressed in 7dF3 clone of human HEK293 cells preincubated for 2 hrs followed by addition of beta-estradiol by lu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  53nMAssay Description:Binding affinity to CDK8/Cyclin C (unknown origin) by reporter displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50154943(CHEMBL3775576)
Affinity DataIC50:  49nMAssay Description:Inhibition of CDK8-mediated STAT1 phosphorylation at serine727 in human SW620 cells harboring APC mutantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed