BDBM50157547 2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4-one::7,8,3',4'-tetrahydroxyflavone::CHEMBL222541

SMILES Oc1ccc(cc1O)-c1cc(=O)c2ccc(O)c(O)c2o1

InChI Key InChIKey=ARYCMKPCDNHQCL-UHFFFAOYSA-N

Data  8 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50157547   

TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human telomerase from HEK293 cell extracts by Flash-Plate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Keimyung University

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Institute For Theoretical Medicine

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  70nMAssay Description:Non-competitive inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  204nMAssay Description:Inhibition of human recombinant BRD4-BD2 expressed in Escherichia coli using C-Terminal-biotinylated histone H4 peptide as substrate preincubated for...More data for this Ligand-Target Pair
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  250nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction follo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  230nMAssay Description:Inhibition of telomerase in human HeLa cells using 5'-AAT CCG TCG AGC AGA GTT-3' as substrate incubated for 15 mins prior to extension reaction by te...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  740nMAssay Description:Inhibition of telomerase activity (unknown origin) in cell free system using sulforhodamine labeled primer measured after 30 mins by telomerase repea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Bu-Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50157547(2-(3,4-dihydroxyphenyl)-7,8-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  200nMAssay Description:Inhibition of telomerase in human HEK293 cells by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed