BDBM50158838 2-{4-[2-(4-chlorophenyl)-5-(4-hydroxyhexahydro-1-pyridinylcarbonyl)benzyloxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylic acid::2-{4-[4''-Chloro-4-(4-hydroxy-piperidine-1-carbonyl)-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid::2-{4-[4'-chloro-4-(4-hydroxypiperidine-1-carbonyl)biphenyl-2-ylmethoxy]-2-fluorophenyl}-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid::CHEMBL368589
SMILES OC1CCN(CC1)C(=O)c1ccc(c(COc2ccc(-c3nc4cc(ccc4n3C3CCCCC3)C(O)=O)c(F)c2)c1)-c1ccc(Cl)cc1
InChI Key InChIKey=GVEQGAVYRVXEKL-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50158838
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: <6nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+7nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+7nMAssay Description:Inhibition of Hepatitis C virus genotype 1 NS5B polymerases lacking C-terminal 47 amino acid residues expressed in Escherichia coli after 60 minMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Irbm (Merck Research Laboratories Rome)
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of HCV 1b BK six His-tagged C-terminal truncated 544 amino acid NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair