BDBM50160284 CHEMBL3785379

SMILES Fc1ccc(cc1)[C@@H]1[C@H](N(C2CCN(CC2)C(=O)n2cncn2)C1=O)c1ccc2OCOc2c1

InChI Key InChIKey=XRIROGBLGLPXQI-FGZHOGPDSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50160284   

TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  4.05E+3nMAssay Description:Inhibition of recombinant C-terminal His-tagged human FAAH expressed in sf21 cells using N-arachidonoyl-[14C]-ethanolamine as substrate assessed as r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  4.05E+3nMAssay Description:Inhibition of recombinant C-terminal His-tagged human FAAH expressed in sf21 cells using N-arachidonoyl-[14C]-ethanolamine as substrate assessed as r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of rat MAGLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  10nMAssay Description:Inhibition of MAGL in rat brain membranes preincubated for 20 mins followed by fluorophosphonate-rhodamine addition measured after 30 mins by competi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  196nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  195nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50160284(CHEMBL3785379)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human MAGL expressed in Escherichia coli using 2-arachidonoyl-[3H]-glycerol as substrate incubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed