BDBM50160852 4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane-2,6,8,10-tetraone::CHEMBL361527

SMILES CCC1CC(=O)N(c2ccc(Oc3ccccc3)cc2)C11C(=O)NC(=O)NC1=O

InChI Key InChIKey=QBWALRVIJDSECI-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50160852   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.400nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.400nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.540nMAssay Description:Binding affinity for matrix metalloproteinase 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.540nMAssay Description:Binding affinity for matrix metalloproteinase 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.870nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  4.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  7.20nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  92nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  92nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of TNF-alpha converting enzyme (TACE, ADAM17)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of TNF-alpha converting enzyme (TACE, ADAM17)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibition of matrix metalloprotease-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed