BDBM50165966 CHEMBL191613::[(2,4-Dichloro-phenylamino)-phosphono-methyl]-phosphonic acid::[(2,4-dichloro-phenyl)aminomethylene]-1,1-bisphosphonate

SMILES OP(O)(=O)C(Nc1ccc(Cl)cc1Cl)P(O)(O)=O

InChI Key InChIKey=KASHBTOPZJTDFP-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50165966   

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  7.14E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  7.46E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyrroline-5-carboxylate reductase(Arabidopsis thaliana)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP14 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  3.31E+12nMAssay Description:Inhibitory activity against Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine synthetase, chloroplastic(Zea mays)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamine synthetase, chloroplastic(Zea mays)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of Zea mays cv. Jeff (maize) leaf glutamine synthetase using L-glutamate as substrate assessed as inorganic phosphate production after 20 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyrroline-5-carboxylate reductase(Arabidopsis thaliana)
University Of Ferrara

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of Arabidopsis thaliana P5C assessed as reduction in NADH oxidation incubated at 35 degC up to 10 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetH(+)-exporting diphosphatase(Trypanosoma brucei)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50165966(CHEMBL191613 | [(2,4-Dichloro-phenylamino)-phospho...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei soluble vacuolar pyrophosphatase expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed