BDBM50173832 4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile::4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-[1,7]naphthyridine-3-carbonitrile::4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1R)-1-phenylethyl]amino}-[1,7]naphthyridine-3-carbonitril::CHEMBL200381

SMILES Fc1ccc(Nc2c(cnc3cnc(NCc4cccnc4)cc23)C#N)cc1Cl

InChI Key InChIKey=NMEUKWOOQOHUNA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50173832   

TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50: >4.00E+5nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against human Tpl2 kinase via quantification of MEK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterferon-induced, double-stranded RNA-activated protein kinase(Homo sapiens (Human))
Weill Cornell Medical College

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50:  250nMAssay Description:Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173832(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed