BDBM50181837 (1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-methyl-1Hindazole-3-carboxylate::CHEMBL383577

SMILES Cn1nc(C(=O)OC[C@@H]2CCN3CCC[C@@H]23)c2ccccc12

InChI Key InChIKey=HSJJCSVABNNXON-JSGCOSHPSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50181837   

Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]GR-113808 from 5HT4 receptor in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]GR65630 from 5HT3 receptor in brain cortex from Wistar ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to 5HT2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic beta-2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50181837((1S,7aR)-hexahydro-1H-pyrrolizin-1-ylmethyl 1-meth...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to adrenergic alpha-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed