BindingDB BDBM50182493 CHEMBL3818247::US9512121, 22

BDBM50182493 CHEMBL3818247::US9512121, 22

SMILES CN1C(=O)COc2c1cnc1ccc(Sc3nnc4c(F)cc(cn34)-c3cnn(C)c3)cc21

InChI Key InChIKey=MFEXYTURXUZOID-UHFFFAOYSA-N

Data 61 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50182493

Hepatocyte growth factor receptor(Homo sapiens (Human))
Jiangsu Hansoh Pharmaceutical

US Patent

BDBM50182493(CHEMBL3818247 | US9512121, 22)

IC50: 2.90nMT: 2°CAssay Description:Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details US Patent

Filter my 61 hits

Targets 57▿
- Epidermal growth factor receptor 4
- Hepatocyte growth factor receptor 2
- Tyrosine-protein kinase Fer 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Receptor tyrosine-protein kinase erbB-4 1
- Tyrosine-protein kinase JAK1 1
- Receptor tyrosine-protein kinase erbB-2 1
- Angiopoietin-1 receptor 1
- Mast/stem cell growth factor receptor Kit 1
- Protein-tyrosine kinase 6 1
- ALK tyrosine kinase receptor 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Mitogen-activated protein kinase 14 1
- Leukocyte tyrosine kinase receptor 1
- Glycogen synthase kinase-3 beta 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Macrophage-stimulating protein receptor 1
- Tyrosine-protein kinase ABL2 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Tyrosine-protein kinase JAK3 1
- Tyrosine-protein kinase JAK2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Tyrosine-protein kinase Fes/Fps 1
- Mitogen-activated protein kinase 1 1
- Ephrin type-A receptor 1 1
- Tyrosine-protein kinase Lck 1
- Ephrin type-A receptor 2 1
- Tyrosine-protein kinase BTK 1
- Tyrosine-protein kinase receptor UFO 1
- Insulin-like growth factor 1 receptor 1
- High affinity nerve growth factor receptor 1
- Serine/threonine-protein kinase N2 1
- Serine/threonine-protein kinase N1 1
- Tyrosine-protein kinase SYK 1
- Fibroblast growth factor receptor 4 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 2 1
- Fibroblast growth factor receptor 1 1
- Vascular endothelial growth factor receptor 3 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 2 1
- Vascular endothelial growth factor receptor 1 1
- Fibroblast growth factor receptor 3 1
- Tyrosine-protein kinase Fyn 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Tyrosine-protein kinase Lyn 1
- Protein kinase C alpha type 1
- Platelet-derived growth factor receptor alpha 1
- Protein kinase C zeta type 1
- Cyclin-dependent kinase 2 1
- Ephrin type-B receptor 1 1
- Ephrin type-B receptor 2 1
- Tyrosine-protein kinase Yes 1
- Platelet-derived growth factor receptor beta 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
Publications 2▿
- Bioorg Med Chem 24: 3483-93 (2016) 60
- US Patent US9512121 (2016) 1
Institutions 2▿
- Southeast University 60
- Jiangsu Hansoh Pharmaceutical 1
Affinity: 0.70 to 3.0E+4 nM▿
- IC50 61
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1